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I found some made from the muscadine grape at the Old South winery in Natchez, but all the rest that all the other vitamin companies is made from the root of the knot weed plant and I have been told it is imported from China. I contacted the research doctor at M. D. Anderson cancer Center and he e-mail back some regular vitamin suppliers. i know they use pharmaceutical grade from Canada but cannot find out.. Thanks for any help.

I want to buy the best Resveratrol I can online for my own personal use.

But I’ve read that some suppliers don’t really supply very good resveratrol quality.

What’s the best supplier of the best resveratrol I can find online?

Thanks!

Does just the plain concord grape jelly have any?

Researchers at the Harvard Medical School and the National Institute on Aging report that a natural substance found in red wine, known as resveratrol, offsets the bad effects of a high-calorie diet in mice and significantly extends their lifespan. Research at the Northeastern Ohio Universities College of Medicine and Ohio State University indicates that resveratrol has direct inhibitory action on cardiac fibroblasts and may inhibit the progression of cardiac fibrosis. Furthermore, researchers discovered that the liver and other systems in obese mice remained healthy (when they should not have) and fat related deaths dropped thirty one percent for those mice given a Resveratrol supplement.

Research by Harvard Medical School Professor of Pathology David Sinclair, MD has shown that resveratrol extends the life span of mice by up to twenty four percent and the life span of other animals by as much as fifty nine percent. Another way this research differs from earlier work is that it looks specifically at the expression of genes known to be affected by aging in several important tissue types. The group explored the influence of the agent on heart, muscle and brain by looking for changes in gene expression in those tissues.

Insulin and glucose levels in mice on the high fat plus resveratrol diet were closer to the mice on standard diet than to the mice on the high fat diet. Resveratrol again demonstrated changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin like growth factor-1 levels, increased AMP activated protein kinase and peroxisome proliferator activated receptor-gamma coactivator 1alpha activity, increased mitochondrial number, and improved motor function. But, in contrast resveratrol treatment had no significant effect on body weight, serum cholesterol, radial bone growth, epithelial cell height, or messenger RNA levels for insulin-like growth factor I.

Resveratrol supplements on the market today may contain anywhere from 10 to 150 mg of resveratrol per pill, but the effective doses for chronic disease prevention in humans are not known. Resveratrol is not known to be toxic or cause adverse effects in humans, but there have been only a few controlled clinical trials to date. However since there aren’t studies in humans, it’s impossible to say how much resveratrol is needed to create health benefits.

The amount of Resveratrol in food varies greatly. Of course, understanding exactly how procyanidins work in the human body remains to be investigated, and the researchers plan to dose people with the compound in a future clinical trial. Resveratrol is a good antioxidant in any potency to help reduce oxidative stress, improving the immune system, cardiovascular system, and all other parts of the body that benefit from antioxidants. ]]> http://benefitsofresveratrol.com/does-resveratrol-extend-ones-lifespan/feed/ 0 http://benefitsofresveratrol.com/antioxidents_chocolate_red_wine/ http://benefitsofresveratrol.com/antioxidents_chocolate_red_wine/#comments Thu, 08 Jan 2009 00:42:55 +0000 http://benefitsofresveratrol.com/?p=156 There’s now good evidence that it’s not just in fruits and vegetables that health promoting anti-oxidant flavonoids are to be found. These powerful compounds have also been identified in tea, particularly green tea, red wine, beer and even chocolate. One of the most powerful of these compounds is called resveratrol and is found in red wine and several varieties of dark berries and fruits. So if you’ve ever suspected that many of those who advocate healthy diets are motivated more by denying you your little pleasures than a genuine interest in your well being, now may be the time to take a little revenge.

Flavonoids occur widely in fruits and vegetables and their principal function appears to be to protect these plants from disease and the damage which may be caused to them by extremes of light or heat. It has long been suspected, however, that the well established health protecting and curative properties of the many plants commonly used in folk remedies for humans may also be due to flavonoids. And there is now abundant evidence to support the idea that certain flavonoids, particularly those of the polyphenol type such as resveratrol, possess potent anti-inflammatory and anti-oxidant properties.

Two of the biggest premature killers in the affluent Western world, as well as major causes of disability and early loss of independence, are stroke and heart disease. Both frequently follow on the development of the cardiovascular disease, atherosclerosis, otherwise known as hardening of the arteries, and it is known that the oxidation of low density lipids (LDL), the blood fats known as “bad cholesterol”, is one of the major causes of this condition. The prevention of LDL oxidation is one of the key functions of vitamin E, the body’s most important fat-soluble anti-oxidant, but antioxidant flavonoids are also known to play a role. Consistent research findings confirming this benefit of flavonoid anti-oxidants have led successive governments and health agencies to urge the public to consume at least five daily servings of fresh fruits and vegetables, and the evidence indeed suggests that such high flavonoid diets are linked to a reduced risk of heart disease and perhaps even some cancers. They go as far as to suggest that a glass of wine and a bit of chocolate are fine and heaslthy addidtions to your diet.
If you’s rather not indulge in a daily alcoholic drink, resveratrol is now available in supplelmental form.

But it’s not just the flavonoids in fruits and vegetables that may have these effects. Much attention, for example, has recently been paid to the so-called “French Paradox”, whereby France boasts a surprisingly low rate of heart disease and related conditions, given the preponderance of saturated animal fat in its national diet. There has been much speculation that the low rate of this disease, by the standards of advanced Western nations, may be linked with relatively high consumption of red wine (resveratrol), and analysis of the anti-oxidants in this drink, also found in red grape juice, suggests that the theory may have some substance.

And at least one major study has suggested that the incidence of stroke is substantially reduced in older people, otherwise a very high risk group for this illness, who regularly drink substantial quantities of tea, which is also rich in anti-oxidant polyphenols, but whose diet tends to be low in fresh fruits and vegetables.

As well as red wine (resveratrol) and tea, there is now also evidence that anti-oxidant flavonoids may be found in beer and even chocolate. But in fact this is not as surprising as it may at first appear. The coca beans which are the primary ingredient of chocolate are a good source of polyphenols, and were known to ancient civilisations for their medicinal properties. Broadly speaking, the darker the chocolate the richer it will be in the particular flavonoids derived from the beans, which are powerful anti-oxidant agents not commonly found elsewhere.

The latest research seems to offer good evidence that the flavonoids particular to dark chocolate (procyanidins) may have a useful role in helping to prevent the oxidation of the LDL, “bad cholesterol”, which is, as noted above, a key precursor of serious cardiovascular disease. Procyanidins also appear to work closely with vitamin E, the body’s most important fat-soluble anti-oxidant, sparing the vitamin to work more effectively, and may also help to prevent excessive clotting or “stickiness” of the blood. Procyanidins are readily absorbed by the body following the consumption of dark chocolate and appear to have a significant overall anti-oxidant effect in the cardiovascular system.

But of course it’s not all good news. You’ll be only too well aware of the health reasons why it would be unwise to rely on tea, red wine, beer or chocolate as your principal sources of dietary anti-oxidant flavonoids. De-caffeinated teas are available, however, and dark chocolate is relatively low in sugar and fat; whilst all the evidence suggests that moderate consumption of alcohol may protect against a variety of conditions, including heart disease. Red wine (resveratrol), in particular, is rich in the anti-oxidant flavonoids which appear to offer significantly enhanced protection. The potent antioxident resveratrol is also available in over the counter supplement form.

As always, the key is balance; and in the context of an otherwise healthy diet, particularly one rich in fruit and vegetables, there is no reason why these highly enjoyable luxury foods and beverages should not make an important contribution to your overall level of anti-oxidant intake.